Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

PLOS Pathogens

Kacie Rice¹  Timothy Palzkill¹  Shrenik C. Mehta¹ 

关键词: Hydrolysis;    Antibiotic resistance;    Antibiotics;    Enzymes;    Substitution mutation;    Thermal stability;    Penicillin;    Enzyme kinetics;   

DOI  :  10.1371/journal.ppat.1004949

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

Unknown