Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases

PLOS Pathogens

Craig B. Wilen¹  Jeffrey C. Miller¹  Michael C. Holmes¹  Joshua Kahn¹  Frederic D. Bushman¹  James A. Hoxie¹  Jianbin Wang¹  Robert W. Doms¹  Carl H. June¹  Anthony J. Secreto¹  Scott A. Sherrill-Mix¹  James L. Riley¹  Andrea P. O. Jordan¹  Bruce A. Bunnell¹  Kenneth A. Kim¹  Philip D. Gregory¹  Pyone P. Aye¹  Gary Lee¹  Andrew A. Lackner¹  Edward J. Rebar¹  John C. Tilton¹  Gwenn A. Danet-Desnoyers¹  Sean C. Patro¹ 

关键词: T cells;    Cell disruption;    HIV-1;    HIV;    HIV infections;    Mouse models;    Zinc finger nucleases;    Coreceptors;   

DOI  :  10.1371/journal.ppat.1002020

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

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