Serum levels of interleukin-6, tumor necrosis factor-alpha and interferon-gama in infants with and without dengue

Revista da Sociedade Brasileira de Medicina Tropical

Restrepo, Berta Nelly¹  Dirección Seccional de Salud de Antioquia, Antioquia, Colombia¹  Salazar, Clara Lina¹  Universidad CES, Medellin, Colombia¹  Alvarez, Luis Gonzalo¹  CES, Antioquia, Colombia¹  Ospina, Marta¹  Isaza, Diana María¹  Ramírez, Ruth¹  Universidad de Antioquia, Antioquia, Colômbia¹ 

关键词: Dengue;    IL-6;    TNF-a;    IFN-g;    Children;   

DOI  :  10.1590/S0037-86822008000100002

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

This study compared the serum levels of IL-6, TNF-a and IFN-g, in children under 1 year of age with and without dengue. Sera were collected from a total of 41 children living in the Department of Antioquia, Colombia (27 patients with dengue and 14 controls). The results showed higher cytokine levels in children with dengue than without dengue, with statistically significant differences for IL-6 and IFN-g. No statistically significant differences were found between clinical forms, although IL-6 and IFN-g levels were higher in dengue fever cases than in dengue hemorrhagic fever cases. On the other hand, TNF-a levels were higher in dengue hemorrhagic fever than in dengue fever. The levels of IL-6 and TNF-a were higher in secondary infection than in primary infection, although IFN-g levels were higher in primary infection. These results suggest that IL-6, TNF-a and IFN-g are involved in dengue infection independently of the clinical form.

【 授权许可】

Unknown