Inflammatory parameters in saliva and blood from healthy children and adolescents

Revista Cubana de Estomatología

Navas Perozo, Rita Mireya¹  Pedreañez Santana, Adriana Beatriz¹  Morón Medina, Alejandra Isabel¹  Viera Sirit, Ninoska Tahis¹  Morales Rojas, Thais Teresita¹ 

[1] Universidad de Zulia, Venezuela

关键词: IL-1;    IL-6;    TNF-a;    sustancias reactivas al ácido tiobarbitúrico;    O2-;    saliva;    sangre;   

DOI  :  

学科分类：基础医学

来源: SciELO

【 摘 要 】

At present times, there is interest in the use of saliva as a diagnosis, prediction and progression alternative of different pathologies in relation to the body fluids. To correlate the concentrations of IL-1, IL-6, TNF-a, substances reactive to thiobarbituric acid (RSTBA) and O2- in the saliva and blood of systematically healthy children and adolescents. A cross-sectional study was performed in 23 healthy children and adolescents aged from 4 to 17 underwent to clinical tests to demonstrate the oral conditions and immunological to identify the cytokine levels and the RSTBAs by colorimetry trial. There was a significant difference in saliva samples compared to that of peripheral blood in study cytokines and RSTBAs: IL-1 (blood: 1.646 ± 0.13 pg/mL, saliva: 552.36 ± 75.7 pg/mL; IL-6 (blood: 3.506 ± 1.85 pg/mL, saliva: 26.89 ± 9.97 pg/mL: TNF-a (blood: 12.91 ± 3.05 pg/mL, saliva: 43.56 ± 6.44 pg/mL), RSTBA (blood: 9.46 ± 3.26 nmol/mL, saliva: 1.26 ± 0.03 nmol/mL). There was not a statistically significant difference among blood and saliva samples for IL-1, IL-6 and RSTBA values. As regards TNF-a it was demonstrated a significant correlation, rs= 0.78. There was not evidence of cells positive to O2 in study samples. Results of correlation analysis obtained among the saliva and serum samples not offer evidences that saliva may be used as body fluid allows substituting the serum determination of IL-1, IL-6 and RSTBA. In the case of the TNF-a, there was a significant correlation, which could to propose the possible substitution of serum samples for the salivary ones.

【 授权许可】

CC BY-NC