Evaluation of the polymorphisms in methylenetetrahydrofolate reductase gene and the levels of folate and B12 in HIV-infected patients under antiretroviral therapy

Revista da Sociedade Brasileira de Medicina Tropical

Costa, Paulo Inácio da¹  Tagliavini, Sandra Antônia¹  Malavazi, Iran¹  Mikawa, Angela Yumico¹  Universidade Estadual Paulista¹  Abrão, Emiliana Pereira¹  Universidade Estadual Paulista, Araraquara¹ 

关键词: HIV;    B12;    folate;    MTHFR polymorphisms;    Coronary artery disease;   

DOI  :  10.1590/S0037-86822004000600008

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

In this study we sought to investigate the B12 and folate levels regarding the influence of methylenetetrahydrofolate reductase genotypes, immunological profile and antiretroviral therapy in the Brazilian HIV-infected population. The study group comprised 89 HIV-infected individuals and 29 blood donors. There was a decrease in the B12 levels in the HIV-infected group with higher TCD4+ lymphocyte counts. No differences in the genotype distribution for methylenetetrahydrofolate reductase polymorphisms between the HIV-infected individuals and the controls were found. HIV-infected individuals carrying the C677C genotype presented lower B12 levels (313.91 ± 154.05) than those with the same genotype in the control group (408.27 ± 207.69). Also, the antiretroviral therapy was not a source of variation of the folate and B12 serum levels. Further studies are needed to reanalyze the prevalence of low levels of folate and B12 and hyperhomocisteinemia among HIV-infected patients with regard to the use of HAART and the increased life expectancy of such patients.

【 授权许可】

Unknown