Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial

Frontiers in Public Health

Keith L. Keene¹ 

关键词: VISP;    association;    GWAS;    one-carbon metabolism;    B12;    B6;    folate;   

DOI  :  10.3389/fpubh.2014.00112

学科分类：卫生学

来源: Frontiers

【 摘 要 】

Background: B vitamins play an important role in homocysteine metabolism, with vitamin deficiencies resulting in increased levels of homocysteine and increased risk for stroke. We performed a genome-wide association study (GWAS) in 2,100 stroke patients from the Vitamin Intervention for Stroke Prevention (VISP) trial, a clinical trial designed to determine whether the daily intake of high-dose folic acid, vitamins B6, and B12 reduce recurrent cerebral infarction.

【 授权许可】

CC BY