Hepatitis B and C virus infection and the hepatocellular carcinoma in the east Amazon, Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Demachki, Samia¹  Fundação Nacional de Saúde, Belém¹  Fundação Hospital Santa Casa de Misericórdia do Pará, Belém¹  Miranda, Esther Castello Branco Mello¹  Universidade Federal do Pará¹  Soares, Manoel do Carmo Pereira¹  Barbosa, Maria Silvia de Brito¹  Amaral, Ivanete do Socorro Abraçado¹  Bensabath, Gilberta¹  Moia, Lizomar de Jesus Pereira¹  Cruz, Ermelinda do Rosário Moutinho da¹  Araújo, Marialva Tereza Ferreira de¹  Conde, Simone Regina Souza da Silva¹ 

关键词: Hepatitis B and C;    Hepatocellular carcinoma;    Serology;    Molecular biology;   

DOI  :  10.1590/S0037-86822004000700007

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

In order to contribute to a better understanding of the possible role of hepatits B and C in the etiopathogenis of HCC in the East Amazon, there were studied 36 patients in Belém/PA. Serological hepatitis markers were evaluated and polymerase chain reaction assays were used to detect HBV-DNA and HCV-RNA. Alcohol abuse was observed in 33.3% and cirrhosis in 83.3%. In 88.9% of the sample, one or more hepatitis B markers were positive. Also, 8.3% those patients had anti-HCV simultaneously positive. The HBsAg serological test was positive in 58.3%; anti-HBc in 86%; anti-HBe in 85.7%; anti-HBe in 9.5%; IgM anti-HBc in 57.1%. The HBV DNA was found in 37.7% and in 65% of the HBsAg positive. The HCV RNA was detected in 8.5% and in 100% of' the patients positive to anti-HCV. The AFP was above the normal value in 88.9% of patients, with levels up to 400ng/ml in 75% of them. In conclusion, hepatitis B virus infection seems to be important in the etiology of HCC and improving measures such immunization and screening in the risk population should be emphasyzed.

【 授权许可】

Unknown