Serological and molecular retrospective analysis of hepatitis E suspected cases from the Eastern Brazilian Amazon 1993-2014

Revista da Sociedade Brasileira de Medicina Tropical

关键词: Latin America;    HEV;    Serology;    Molecular biology;    Acute hepatitis;   

DOI  :  10.1590/0037-8682-0465-2018

来源: DOAJ

【 摘 要 】

AbstractINTRODUCTIONWe evaluated the anti-hepatitis E virus (HEV) antibody prevalence and HEV-RNA in archived serum samples of non-A-C hepatitis, or suspected cases of HEV infection from the Eastern Brazilian Amazon from 1993 to 2014.METHODSSerum samples (n = 318) were tested using ELISA and immunoblotting, and screened for HEV-RNA by RT-qPCR.RESULTSAnti-HEV IgM and IgG were detected in 3.4% (11/318) and 5.9% (19/318) of the samples, respectively. All samples were HEV-RNA negative.CONCLUSIONSHEV was detected at a low prevalence. Broader serological and molecular evaluation of HEV infection in the Amazon region should be carried out.

【 授权许可】

Unknown