The effect of the carotenoid bixin and annatto seeds on hematological markers and nephrotoxicity in rats subjected to chronic treatment with cisplatin

Revista Brasileira de Farmacognosia

Achaval, Matilde¹  Centro Universitário Metodista, Porto Alegre, Brazil¹  Jong, Erna V. de¹  Souza, Lucéia F.¹  Rios, Alessandro¹  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil¹  Medeiros, Niara da S.¹  Barbosa, Sílvia¹  Pagno, Carlos Henrique¹  Santos, Paula C.P. dos¹ 

关键词:  Cisplatin;    Bixin;    Annatto;    Cell differentiation;    Nephrotoxicity;    Antioxidant;   

DOI  :  10.1016/j.bjp.2016.03.005

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

This study assessed the protective effect of the carotenoid bixin and annatto seeds against possible nephrotoxicity induced with a single peritoneal administration of pharmacological cisplatin in male Wistar rats. After 48 h, the blood cell differential count showed a significant reduction in neutrophil counts in rats that received a diet rich in bixin when compared to the group that received only cisplatin. The use of cisplatin led to an increase in kidney weight. The carotenoid bixin attenuated renal injury, characterized by increased polymorphonuclear infiltration. No protective effect was observed with respect to Annatto. These results demonstrate the role of toxic cisplatin and suggest that bixin affords a protective effect against cisplatin-induced nephrotoxicity in adult Wistar rats.

【 授权许可】

Unknown