The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo

Revista Brasileira de Farmacognosia

Fu, Xueyan¹  Ningxia Medical University, Yinchuan, China¹  Zhang, Xinhui¹  Zhao, Xin¹  Zhang, Yuanbin¹  Wang, Bing¹  Yin, Lei¹  Gao, Qinghan¹  Wu, Xiuli¹  Sun, Weihong¹ 

关键词:  Essential oil;    Carbon tetrachloride;    Hepatoprotective effects;    In vivo;    H&;    E;    GC–MS;   

DOI  :  10.1016/j.bjp.2016.01.001

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

To study the hepatoprotective effect of the essential oil of Artemisia capillaris Thunb., Asteraceae, on CCl4-induced liver injury in mice, the levels of serum aspartate aminotransferase and alanine aminotransferase, hepatic levels of reduced glutathione, activity of glutathione peroxidase, and the activities of superoxide dismutase and malondialdehyde were assayed. Administration of the essential oil of A. capillaris at 100 and 50 mg/kg to mice prior to CCl4 injection was shown to confer stronger in vivo protective effects and could observably antagonize the CCl4-induced increase in the serum alanine aminotransferase and aspartate aminotransferase activities and malondialdehyde levels as well as prevent CCl4-induced decrease in the antioxidant superoxide dismutase activity, glutathione level and glutathione peroxidase activity (p < 0.01). The oil mainly contained β-citronellol, 1,8-cineole, camphor, linalool, α-pinene, β-pinene, thymol and myrcene. This finding demonstrates that the essential oil of A. capillaris can protect hepatic function against CCl4-induced liver injury in mice.

【 授权许可】

Unknown