Evaluation of post-surgical healing in rats using a topical preparation based on extract of Musa sapientum L., Musaceae, epicarp

Revista Brasileira de Farmacognosia

Universidade Católica de Santos, Santos, Brazil¹  Dellova, Deise C. A. L.¹  Lino, Priscila B.¹  Archondo, Márcia E. D. L.¹  Corrêa, Cleber F.¹  Universidade de São Paulo, Pirassununga, Brazil¹  Universidade do Grande ABC, Santo André, Brazil¹ 

关键词: Musa sapientum;    apple banana;    tannin;    tissue repair;   

DOI  :  10.1590/S0102-695X2011005000052

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Considering that oral preparations made with peel green bananas (e.g. flour and extracts) demonstrated healing effects on mucous membranes and skin, this study evaluated the healing and the antimicrobial property of a topical preparation based on extract of Musa sapientum L., Musaceae, (apple banana) in surgically induced wounds in the skin of male Wistar rats, 100 g. The extract was obtained by decoction, the presence of tannins was detected by phytochemical screening and 10% of the extract was incorporated into the carbopol gel (CMS gel). The processes of healing and bacterial isolation were evaluated in the following experimental groups: control (no treatment), treatment with placebo or with the CMS gel. The healing of surgical wounds treated with the CMS gel was faster when compared with the control and placebo groups and the treatment with CMS gel also inhibited the growth of pyogenic bacteria and enterobacteria in the wounds. The results indicate that the extract of Musa sapientum epicarp has healing and antimicrobial properties (in vivo), probably, due to tannins.

【 授权许可】

Unknown