Antihypertensive effect of methanolic extract of Passiflora nepalensis

Revista Brasileira de Farmacognosia

Patel, Sita Sharan¹  Shrestha, Bhupendra¹  Cardiovascular Research Unit, Majhitar, India¹  Gauthaman, Karunakaran¹  Verma, Neelesh Kumar¹ 

关键词: antihypertensive effect;    heart rate;    Passiflora nepalensis.;   

DOI  :  10.1590/S0102-695X2011005000012

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The present study was designed to investigate the antihypertensive effect of methanolic extract of the whole plant of Passiflora nepalensis Walp., Passifloraceae, (MPN) in renal hypertensive and normotensive rats. The blood pressure, pulse pressure, and heart rate fell dose-dependently in renal hypertensive and normotensive rats after intravenous administration of 75, 150, and 225 mg/kg MPN, suggesting that MPN possesses antihypertensive, hypotensive and negative chronotropic effects. The effect at doses of 150 and 225 mg/kg of MPN were more pronounced than that of 75 mg/kg body weight. Thus, the present study reveals that MPN exerts antihypertensive effect against renal hypertension.

【 授权许可】

Unknown