Revista Brasileira de Farmacognosia | |
Antinociceptive activity of Ipomoea imperati (Vahl) Griseb., Convolvulaceae | |
Moura, Sérgio H. P.1  Paula-Zurron, Ana Claudia B. De1  Universidade Estadual de Campinas, Campinas, Brazil1  Imamura, Paulo M.1  Aur, Carlos R.1  Petraglia, Nilva M. M. A.1  Catanzaro-Guimarães, Sérgio A.1  Freitas, José C. De1  Universidade de São Paulo, São Paulo, Brazil1  Universidade do Sagrado Coração, Bauru, Brazil1  | |
关键词: Ipomoea imperati; Convolvulaceae; pain; analgesic activity; opioid system.; | |
DOI : 10.1590/S0102-695X2010000200008 | |
来源: Sociedade Brasileira de Farmacognosia | |
【 摘 要 】
Ipomoea imperati (Vahl) Griseb., Convolvulaceae, is used in folk medicine for the treatment of inflammation, swelling and wounds, as well as to treat pains after childbirth and for stomach problems. Administration of ethanol extract, lipid and aqueous fraction of I. imperati(300, 100 and 200 mg/kg) significantly inhibited the abdominal constriction in mice induced by acetic acid; increased the sleeping time evoked by pentobarbital sodium and showed a significant activity by inhibiting formalin-induced paw edema in mice. The same dose of I. imperatialso raised the pain of mice in the hot-plate test and increased the latency at all observation times. The pre-treatment of the animals with naloxone (5 mg/kg, i.p.) suggested the participation of the opioid system in the antinociceptive effect of Ipomoea imperati.
【 授权许可】
Unknown
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