Antinociceptive activity of Ipomoea imperati (Vahl) Griseb., Convolvulaceae

Revista Brasileira de Farmacognosia

Moura, Sérgio H. P.¹  Paula-Zurron, Ana Claudia B. De¹  Universidade Estadual de Campinas, Campinas, Brazil¹  Imamura, Paulo M.¹  Aur, Carlos R.¹  Petraglia, Nilva M. M. A.¹  Catanzaro-Guimarães, Sérgio A.¹  Freitas, José C. De¹  Universidade de São Paulo, São Paulo, Brazil¹  Universidade do Sagrado Coração, Bauru, Brazil¹ 

关键词: Ipomoea imperati;    Convolvulaceae;    pain;    analgesic activity;    opioid system.;   

DOI  :  10.1590/S0102-695X2010000200008

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Ipomoea imperati (Vahl) Griseb., Convolvulaceae, is used in folk medicine for the treatment of inflammation, swelling and wounds, as well as to treat pains after childbirth and for stomach problems. Administration of ethanol extract, lipid and aqueous fraction of I. imperati(300, 100 and 200 mg/kg) significantly inhibited the abdominal constriction in mice induced by acetic acid; increased the sleeping time evoked by pentobarbital sodium and showed a significant activity by inhibiting formalin-induced paw edema in mice. The same dose of I. imperatialso raised the pain of mice in the hot-plate test and increased the latency at all observation times. The pre-treatment of the animals with naloxone (5 mg/kg, i.p.) suggested the participation of the opioid system in the antinociceptive effect of Ipomoea imperati.

【 授权许可】

Unknown