Revista Cubana de Plantas Medicinales | |
Evaluation of the central analgesic activity of the leaves of Maytenus macrocarpa (Ruiz & Pav.) Briq. (chuchuhuasi) | |
León Fernández, Angelica M1  Barrientos Herrera, Alejandro J1  Maraví Rengifo, Julio E1  Urbano Farje, Orlando J1  Salazar Granara, Alberto A1  Tupia Céspedes, Lourdes L1  Turriate Montaldo, Yessica1  | |
[1] Centro de Investigación de Medicina Tradicional y Farmacología, Lima, Perú | |
关键词: Maytenus macrocarpa; leaves; pain; analgesic activity; tail flick; Tramadol; | |
DOI : | |
学科分类:药理学 | |
来源: Editorial Ciencias Medicas | |
【 摘 要 】
Introduction: Maytenus macrocarpa (Ruiz & Pav.) Briq (chuchuhuasi) is a Peruvian medicinal plant which has been attributed antidysenteric, antidiarrheal, analgesic and anti-inflammatory effects, among others.Objective: explore the central analgesic activity of M. macrocarpa leaves in mice using the tail-flick model.Methods: fifty albino mice (25 g average weight) were divided into 5 groups and administered the following substances by oral route: M. macrocarpa 1 000 and 1 500 mg/kg, Tramadol 10 mg/kg, distilled water (placebo) 0.1 ml/10 g, and a control group. Pain was evaluated by estimating the average latency period after taking 6 measurements at 30 minute intervals. Percent maximum possible effect (% MPE) was also determined.Results: baseline time for chuchuhuasi 1 000 mg/kg was 2.781 seconds vs. 4.135 seconds at 120 minutes. Baseline time for chuchuhuasi 1 500 mg/kg was 2.467 seconds vs. 4.385 seconds at 180 minutes; p value vs. control was p>0.05. Baseline time for Tramadol was 2.030 seconds vs. 5.173 seconds at 30 minutes; p value vs. control was p>0.05. The placebo group was not significant. % MPE was 19 % for chuchuhuasi 1 000 mg/kg, 14 % for chuchuhuasi 1 500 mg/kg and 37 % for Tramadol.Conclusion:the central analgesic effect of M. macrocarpa leaves on the tail-flick model was not significant. Percent maximum possible effect was 19 % with chuchuhuasi 1 000 mg/kg.
【 授权许可】
CC BY-NC
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