Ukulactone C, a new NADH-fumarate reductase inhibitor produced by Talaromyces sp. FKI-6713

The Journal of General and Applied Microbiology

Kenichi Nonaka²  Mihoko Mori²  Satoshi Ōmura¹  Satoru Kaifuchi²  Kazuro Shiomi²  Rokuro Masuma¹ 

[1] Kitasato Institute for Life Sciences, Kitasato University;Graduate School of Infection Control Sciences, Kitasato University

关键词: electron transport enzyme inhibitor;    NADH-fumarate reductase;    Talaromyces;    ukulactone;   

DOI  :  10.2323/jgam.61.57

学科分类：微生物学和免疫学

来源: Applied Microbiology, Molecular and Cellulrar Biosciences Research Foundation

【 摘 要 】

Screening for NADH-fumarate reductase inhibitors led to the isolation of a new ukulactone analog, ukulactone C, as a major polyene compound produced by Talaromyces sp. FKI-6713. The structure of the compound was elucidated as a reduced analog of ukulactone A by 1D- and 2D-NMR experiments. Ukulactone C possessed a potent inhibitory activity (IC50 = 62 nM) against NADH-fumarate reductase of the roundworm Ascaris suum in vitro.

【 授权许可】

Unknown