Bioactive Compounds Produced by Strains of Penicillium and Talaromyces of Marine Origin

Marine Drugs

Rosario Nicoletti¹  Antonio Trincone² 

[1] Council for Agricultural Research and Agricultural Economy Analysis, Rome 00184, Italy;Institute of Biomolecular Chemistry, National Research Council, Pozzuoli 80078, Italy;

关键词: bioactive metabolites;    chemodiversity;    marine fungi;    Penicillium;    Talaromyces;   

DOI  :  10.3390/md14020037

来源: DOAJ

【 摘 要 】

In recent years, the search for novel natural compounds with bioactive properties has received a remarkable boost in view of their possible pharmaceutical exploitation. In this respect the sea is entitled to hold a prominent place, considering the potential of the manifold animals and plants interacting in this ecological context, which becomes even greater when their associated microbes are considered for bioprospecting. This is the case particularly of fungi, which have only recently started to be considered for their fundamental contribution to the biosynthetic potential of other more valued marine organisms. Also in this regard, strains of species which were previously considered typical terrestrial fungi, such as Penicillium and Talaromyces, disclose foreground relevance. This paper offers an overview of data published over the past 25 years concerning the production and biological activities of secondary metabolites of marine strains belonging to these genera, and their relevance as prospective drugs.

【 授权许可】

Unknown