Antifungal Polyketides and Other Compounds from Amazonian Endophytic Talaromyces Fungi

Journal of the Brazilian Chemical Society

Silva, Sarah R. S. da¹  Souza, Mayane P. de²  Bianco, Eliana A.³  Silva, Paulo H. F. da⁴ 

[1] Universidade Federal de São Carlos, São Carlos, Brazil;Universidade Federal do Amazonas, Manaus, Brazil;Universidade Federal do Paraná, Curitiba, Brazil;Universidade do Estado do Amazonas, Manaus, Brazil

关键词: Amazon region;    cordyanhydrides;    endophytic fungi;    Talaromyces;    xanthone dimers.;   

DOI  :  10.21577/0103-5053.20170176

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The continuous search for biologically active compound candidates pushes the pursuit of new substances produced by diverse organisms. Endophytic fungi are known as a promising source of metabolites with several biological activities. Based on the rich Amazonian biodiversity and the chemical potential of microbial sources, three Talaromyces strains, all major endophytes from their respective host plants, were studied aiming at the isolation of biologically active secondary metabolites. Through classical chromatographic approaches, 13 compounds were isolated from the antimicrobial extracts of the studied strains. From these, polyketides, steroids, anhydrides, and phenolic compounds were identified. Among them, two previously undescribed compounds were elucidated based on spectroscopic and spectrometric methods, a homodimer chromanone and a maleic anhydride methyl ester. The antimicrobial activity against a panel of pathogenic microorganisms from extracts, fractions, and isolated compounds was evaluated.

【 授权许可】

CC BY