Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models

Journal of Pharmacological Sciences

Minoru Hasegawa³  Shinji Shimada³  Minoru Narita¹  Mitsunobu Matsumoto⁴  Syuichi Matsushima²  Koichi Masuno²  Takako Miyoshi²  Toshiyuki Kanemasa³  Takako Tomii³  Akira Kato³  Katsumi Koike³  Satoshi Orita⁴  Tsutomu Suzuki¹  Hisanori Ito³  Atsushi Nakamura³  Mikinori Torii²  Kazuhisa Minami³  Tsuyoshi Kihara³ 

[1]Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan

[2]Drug Safety Evaluation, Developmental Research Laboratories, Shionogi & Co., Ltd., Japan

[3]Pain & Neurology, Discovery Research Laboratories, Shionogi & Co., Ltd., Japan

[4]Allergy & Cancer, Discovery Research Laboratories, Shionogi & Co., Ltd., Japan

关键词: oxycodone;    morphine;    fentanyl;    neuropathic pain-like state;    bone cancer pain;   

DOI  :  10.1254/jphs.09139FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(37)Cited-By(30)Morphine, oxycodone, and fentanyl are clinically prescribed drugs for the management of severe pain. We investigated whether these opioids possess different efficacy profiles on several types of pain in mouse pain models. When the three opioids were tested in the femur bone cancer model, all of them significantly reversed guarding behavior, whereas the effects on limb-use abnormality and allodynia-like behavior differed among the opioids. Particularly, although oxycodone (5 – 20 mg/kg) and fentanyl (0.2 mg/kg) significantly reversed limb-use abnormality, not even a high dose of morphine (50 mg/kg) could reverse it. When the effects of these opioids were examined in a sciatic nerve ligation (SNL) model of neuropathic pain, oxycodone was the most effective, producing an antinociceptive effect without affecting the withdrawal threshold of sham-treated animals. When the effects of these opioids were examined with the tail-flick test using naive animals, oxycodone, morphine, and fentanyl exhibited antinociceptive effects on thermal nociception. These results show that the three opioids exhibit different efficacy outcomes in multiple pain models and that the efficacy profile of oxycodone does not overlap those of morphine and fentanyl.

【 授权许可】

Unknown