Targeting the Orexin System for Prescription Opioid Use Disorder

Brain Sciences

Rémi Martin-Fardon¹  Alessandra Matzeu¹ 

[1] Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA;

关键词: Keywords: orexin;    prescription opioid use disorder;    oxycodone;    remifentanil;    fentanyl;   

DOI  :  10.3390/brainsci10040226

来源: DOAJ

【 摘 要 】

Prescription opioids are potent analgesics that are used for clinical pain management. However, the nonmedical use of these medications has emerged as a major concern because of dramatic increases in abuse and overdose. Therefore, effective strategies to prevent prescription opioid use disorder are urgently needed. The orexin system has been implicated in the regulation of motivation, arousal, and stress, making this system a promising target for the treatment of substance use disorder. This review discusses recent preclinical studies that suggest that orexin receptor blockade could be beneficial for the treatment of prescription opioid use disorder.

【 授权许可】

Unknown