Evaluation of Bispectral Index (BIS) as an Indicator of Central Nervous System Depression in Horses Anesthetized with Propofol

Journal of Veterinary Medical Science

Natsuki AKASHI²  Hiroki INOUE¹  William W. MUIR III⁴  Mohammed A. UMAR²  Yumiko KATAYAMA²  Takaharu ITAMI²  Yosuke UCHIDA²  Kazuto YAMASHITA²  Richard A. SAMS³ 

[1] Department of Biosphere and Environmental Sciences, Faculty of Environment Systems, Rakuno Gakuen University;Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Faculty of Environment Systems, Rakuno Gakuen University;Florida Racing Laboratory, College of Veterinary Medicine, University of Florida;Veterinary Clinical Pharmacology Consulting Services

关键词: ispectral index (BIS);    equine;    propofol;   

DOI  :  10.1292/jvms.001465

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(38)Cited-By(7)The bispectral index (BIS) was evaluated as an indicator of central nervous system (CNS) depression in horses anesthetized with propofol. Five non-premedicated horses were anesthetized with 7 mg/kg, IV propofol and the minimum infusion rate (MIR) of propofol required to maintain anesthesia was determined during intermittent positive pressure ventilation in each horse. The BIS was determined 20 min later and after stabilization at 2.0 MIR, 1.5 MIR, and 1.0 MIR. The BIS was also recorded after the cessation of propofol infusion when the horses regained spontaneous breathing and swallowing reflex. The MIR and plasma concentration (Cp) of propofol were 0.20 ± 0.03 mg/kg/min and 17.5 ± 4.0 μg/ml, respectively. The BIS value and Cp were 59 ± 13 and 26.7 ± 8.6 μg/ml at 2.0 MIR, 63 ± 9 and 22.9 ± 9.7 μg/ml at 1.5 MIR, 64 ± 13 and 20.1 ± 5.9 μg/ml at 1.0 MIR, 64 ± 24 and 13.0 ± 2.8 μg/ml at return of spontaneous breathing, and 91 ± 4 and 11.0 ± 3.4 μg/ml when the swallowing reflex returned, respectively. The BIS value was significantly less in anesthetized horses compared to horses once swallowing returned (p=0.025). The BIS value was significantly correlated with the propofol Cp (r=-0.625, p=0.001). There was not a significant difference in the BIS values during the MIR multiples of propofol. The BIS was a useful indicator of awakening but did not indicate the degree of CNS depression during propofol-anesthesia in horses.

【 授权许可】

Unknown