The Minimum Infusion Rate (MIR) of Propofol for Total Intravenous Anesthesia after Premedication with Xylazine in Horses

Journal of Veterinary Medical Science

Takashi YAMANAKA²  Toru FUJINAGA¹  Yutaka MIZUNO²  Kazuomi OKU²  Minoru OHTA² 

[1] Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University;Racehorse Clinic, Miho Training Center, Japan Racing Association

关键词: anesthesia;    equine;    MIR;    propofol;   

DOI  :  10.1292/jvms.67.569

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(29)Cited-By(12)To investigate an adequate infusion rate of propofol for total intravenous anesthesia (TIVA) in horses, the minimum infusion rate (MIR) comparable to the minimum alveolar anesthetic concentration (MAC) of inhalation anesthetic was determined under constant ventilation condition by intermittent positive pressure ventilation (IPPV). In addition, arterial propofol concentration was measured to determine the concentration corresponding to the MIR (concentration preventing reaction to stimulus in 50% of population, Cp50). Further, 95% effective dose (ED95) was estimated as infusion rate for acquiring adequate anesthetic depth. Anesthetic depth was judged by the gross purposeful movement response to painful stimulus. MIR and Cp50 were 0.10 ± 0.02 mg/kg/min and 5.3 ± 1.4 μg/ml, respectively. ED95 was estimated as 0.14 mg/kg/min (1.4MIR).

【 授权许可】

Unknown