Clinical and microbiological observational study on AmpC β-lactamase-producing Enterobacteriaceae in a hospital of Nepal

Brazilian Journal of Infectious Diseases

Neupanea, Sanjiv²  Marasinia, Bishnu Prasad²  Baral, Pankaj²  Lekhaka, Binod²  Shresthac, Basudha³  Ghimirea, Kashi Ram¹ 

[1] Mahidol University, Bangkok, Thailand;Tribhuvan University, Kathmandu, Nepal;Kathmandu Model Hospital, Kathmandu, Nepal

关键词: AmpC β;    -lactamase;    Enterobacteriaceae;    Antibiotic resistance;   

DOI  :  10.1016/j.bjid.2012.09.012

来源: Contexto

【 摘 要 】

Limited information is available regarding AmpC β-lactamase (ABL)-producing Enterobacteriaceae compared to extended-spectrum β-lactamase-producing enterobacteria. Since ABL-producing organisms are often resistant to multiple antimicrobial agents, therapeutic options against these pathogens are limited. Among 230 clinical Enterobacteriaceae isolates, 64 (27.8%) were found to produce ABL in our study. Escherichia coli (83.9%) was a predominant pathogen, followed by Citrobacter freundii (5.2%). A significant proportion of ABL-producing isolates (81.3%) were found to be multidrug resistant against commonly used antibiotics. Univariate analysis showed that prior history of taking antibiotics (odds ratio [OR], 5.278; confidence interval [CI], 2.838-9.817; p < 0.001) and being inpatients (OR, 4.587; CI, 2.132-9.9; p < 0.001) were associated with ABL positivity. Regular antimicrobial resistance surveillance for ABL-producing Enterobacteriaceae is warranted for proper antimicrobial treatment strategy and policy making due to ABL-positive infections.

【 授权许可】

CC BY-NC-ND