Brazilian Journal of Infectious Diseases | |
Clinical and microbiological observational study on AmpC β-lactamase-producing Enterobacteriaceae in a hospital of Nepal | |
Neupanea, Sanjiv2  Marasinia, Bishnu Prasad2  Baral, Pankaj2  Lekhaka, Binod2  Shresthac, Basudha3  Ghimirea, Kashi Ram1  | |
[1] Mahidol University, Bangkok, Thailand;Tribhuvan University, Kathmandu, Nepal;Kathmandu Model Hospital, Kathmandu, Nepal | |
关键词: AmpC β; -lactamase; Enterobacteriaceae; Antibiotic resistance; | |
DOI : 10.1016/j.bjid.2012.09.012 | |
来源: Contexto | |
【 摘 要 】
Limited information is available regarding AmpC β-lactamase (ABL)-producing Enterobacteriaceae compared to extended-spectrum β-lactamase-producing enterobacteria. Since ABL-producing organisms are often resistant to multiple antimicrobial agents, therapeutic options against these pathogens are limited. Among 230 clinical Enterobacteriaceae isolates, 64 (27.8%) were found to produce ABL in our study. Escherichia coli (83.9%) was a predominant pathogen, followed by Citrobacter freundii (5.2%). A significant proportion of ABL-producing isolates (81.3%) were found to be multidrug resistant against commonly used antibiotics. Univariate analysis showed that prior history of taking antibiotics (odds ratio [OR], 5.278; confidence interval [CI], 2.838-9.817; p < 0.001) and being inpatients (OR, 4.587; CI, 2.132-9.9; p < 0.001) were associated with ABL positivity. Regular antimicrobial resistance surveillance for ABL-producing Enterobacteriaceae is warranted for proper antimicrobial treatment strategy and policy making due to ABL-positive infections.
【 授权许可】
CC BY-NC-ND
【 预 览 】
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