Multilocus Sequence Types and Virulence Determinants of Hypermucoviscosity-Positive Klebsiella pneumoniae Isolated from Community-Acquired Infection Cases in Harbin, North China

Japanese Journal of Infectious Diseases

Xiaohong Qiu¹  Fengmin Zhang³  Xiaobei Chen²  Jizi Zhao³  James Opiyo Ogutu³  Jie Chen³  Ming Zhao¹  Wenli Zhang³  Rui Sun³ 

[1] Affiliated Hospital of Harbin Medical University;College of Public Health, Harbin Medical University;Department of Microbiology, Harbin Medical University

关键词: hypermucoviscosity;    Klebsiella pneumoniae;    MLST;    mouse lethality;   

DOI  :  10.7883/yoken.JJID.2015.321

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(23)We investigated the molecular epidemiologic characteristics and virulence of hypermucoviscosity-positive Klebsiella pneumoniae in mainland China. We detected 16 hypermucoviscosity-positive strains in 65 total clinical isolates (24.62%). We found that 68.75% (11/16) of the positive strains had K2 genotype and carried the rmpA and iucA genes. Multilocus sequence typing revealed 5 sequence types (STs): ST65 [7], ST23 [4], ST86 [3], ST412 [1], ST375 [1], whereas the remaining 4 isolates were defined as other STs. The order of the median lethal dose values for the ST types was ST23 (2.19 × 103 CFU/mouse) < ST86 (1.70 × 104 CFU/mouse) < ST65 (5.05 × 107 CFU/mouse) < the other STs (1.90 × 108 CFU/mouse). In conclusion, the K2 with ST65 carrying rmpA and iucA was the most predominant among the hypermucoviscosity-positive K. pneumoniae strains obtained from community-acquired infection cases in Harbin, North China. Sequence types are a valuable tool to predict the risk of K. pneumoniae infection.

【 授权许可】

Unknown