Acute oral toxicity of Solanum torvum Sw. (prendejera)

Revista Cubana de Plantas Medicinales

Jackson Horruitiner, Elizet¹  Puente Zapata, Edgar²  Castillo, Alfredo Alfonso²  Mora Tassé, Yoandra²  Salas Martínez, Hilario²  Betancourt Hernández, Juan²  Pérez Jackson, Liliana² 

[1] Universidad de Ciencias Médicas, Santiago de Cuba, Cuba;Centro de Toxicología y Biomedicina (TOXIMED), Santiago de Cuba, Cuba

关键词: : medicinal plants;    acute toxicity;    toxicity test;    Solanum torvum;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Introduction: Solanum torvum Sw., traditionally known as prendejera, is a medicinal plant used by the population as antimicrobial and anti-inflammatory agent among other properties. No acute toxicity studies are reported on this plant, just long-term toxicity studies.Objectives: to evaluate the acute oral toxicity by the class method using decoction of Solanum torvum leaves and stems orally administered to Sprague Dawley rats. Methods: an acute oral toxicity test based on the class method was conducted. The S.torvum plant decoction was administered in one dose of 2000 mg/kg of body weight. Pathological anatomy studies were performed to analyze the toxicity in the tested substance. Results: the evaluated substance did not show any clinical signs of toxicity or animal deaths; no alterations in the body weight of the experimental models were found. There were no alterations of diagnostic value according to the macroscopic analysis. Conclusions: the tested decoction, orally administered at one dose, is regarded as unclassified for the animal model and the dosage used under the observed experimental conditions.

【 授权许可】

CC BY-NC