Toxicity by repeated doses of Solanum torvum Sw. decoction (prendejera) in rats

Revista Cubana de Plantas Medicinales

Puente Zapata, Edgar¹  Wawoe Díaz, Nioslaymy¹  Mora Tassé, Yoandra¹  Salas, Hilario¹  Alfonso Castillo, Alfredo¹  Betancourt Hernández, Juan¹  Pérez Jackson, Liliana¹  Fong Lores, Onel¹ 

[1] Centro de Toxicología y Biomedicina (TOXIMED), Santiago de Cuba, Cuba

关键词: : medicinal plants;    plant extracts;    toxicity test;    Solanum torvum;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

INTRODUCTION: Solanum torvum Sw., commonly known in Cuban eastern zone as prendejera, belongs to Solanaceae family and is very used due to its traditional medicinal properties as antimicrobial, antiarthritic and anti-inflammatory. OBJECTIVE: to assess the toxicity level by repeated doses for 28 days of leaves and stems decoction of S. torvum by oral route in rats. METHODS: a toxicity trial was made in repeated doses by limit test method for 28 days in a decoction of S. torvum in a 1 000 mg/kg dose, administered by oral route to Sprague Dawley rats. Hematology, blood Biochemistry examinations and anatomical and pathological and histopathological corresponding analyses were made. RESULTS: there were not toxicity signs in animals and no affectations in body weight. The results of histopathological analysis demonstrated the lack of organic damages provoked by the assessed decoction and corroborated the above results. CONCLUSIONS: in trial conditions, the decoction of leaves and stems of S. torvum there were not toxic reactions attributable to essayed substance.

【 授权许可】

CC BY-NC