Acute oral toxicity of Azadirachta indica (Neem Tree)

Revista Cubana de Plantas Medicinales

Puente Zapata, Edgar¹  Mora Tassé, Yoandra¹  Salas Martínez, Hilario¹  Alfonso Castillo, Alfredo¹  Berenguer Rivas, Clara Azalea¹  Betancourt Hernández, Juan¹ 

[1] Centro de Toxicología y Biomedicina, Santiago de Cuba, Cuba

关键词: medicinal plants;    acute toxicity;    toxicity test;    Azadirachta indica;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Introduction: Neem tree, whose scientific name is Azadirachta indica, is a medicinal plant used by its antiseptic, antiviral, antipyretic, antimicrobial, and anti-inflammatory properties, among others. No acute toxicity studies are reported on this plant, just long-term toxicity studies. Objectives: to evaluate the acute oral toxicity by the class method using decoction of Azadirachta indica leaves and stems orally administered to Sprague Dawley rats. Methods: an acute oral toxicity test based on the class method was conducted. The Azadirachta indica plant decoction was administered in one dose of 2 000 mg/kg of body weight. Pathological anatomy studies were performed to analyze the toxicity in the tested substance. Results: the evaluated substance did not show any clinical signs of toxicity or animal deaths; no alterations in the body weight of the experimental models were found. There were no alterations of diagnostic value according to the macroscopic analysis. Conclusions: the tested decoction, orally administered at one dose, is regarded as unclassified for the animal model and the dosage used under the observed experimental conditions.

【 授权许可】

CC BY-NC