Interaction between type I interferon and cyprinid herpesvirus 3 in two genetic lines of common carp Cyprinus carpio

Diseases of Aquatic Organisms

Ikuo Hirono¹  Graham Brogden¹  Marek Matras¹  Dieter Steinhagen¹  Ilgiz Irnazarow¹  Krzysztof Ł. Rakus¹  Hidehiro Kondo¹  Jarosław Chyb¹  Takashi Aoki¹  Mikołaj Adamek¹ 

关键词: CyHV-3;    Koi;    Infection;    Innate immune response;    Interferon stimulated genes;   

DOI  :  10.3354/dao02773

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: Cyprinid herpesvirus 3 (CyHV-3) infection in common carp Cyprinus carpio L. and its ornamental koi varieties can induce the severe systemic disease known as koi herpesvirus disease. This disease is characterised by a rapid replication and spreading of the virus through multiple organs and results in a fast onset of mortality (starting on Day 6 post infection) in up to 100% of infected fish. During the first phase of viral infections, type I interferons (IFNs) have generally been proven to be essential in inducing an innate immune response; however, very little is known about the type I IFN response to herpesviruses in fish. The aim of this work was to study the type I IFN responses during CyHV-3 infection in 2 genetically divergent lines of common carp which presented differing survival rates. Our results show that CyHV-3 induced a systemic type I IFN response in carp, and the magnitude of type I IFN expression is correlated with the virus load found in skin and head kidney. In this in vivo experimental setup, the level of type I IFN response cannot be linked with higher survival of carp during CyHV-3 infection.

【 授权许可】

Unknown