Diseases of Aquatic Organisms | |
Interaction between type I interferon and cyprinid herpesvirus 3 in two genetic lines of common carp Cyprinus carpio | |
Ikuo Hirono1  Graham Brogden1  Marek Matras1  Dieter Steinhagen1  Ilgiz Irnazarow1  Krzysztof Ł. Rakus1  Hidehiro Kondo1  Jarosław Chyb1  Takashi Aoki1  Mikołaj Adamek1  | |
关键词: CyHV-3; Koi; Infection; Innate immune response; Interferon stimulated genes; | |
DOI : 10.3354/dao02773 | |
学科分类:生物科学(综合) | |
来源: Inter-Research | |
【 摘 要 】
ABSTRACT: Cyprinid herpesvirus 3 (CyHV-3) infection in common carp Cyprinus carpio L. and its ornamental koi varieties can induce the severe systemic disease known as koi herpesvirus disease. This disease is characterised by a rapid replication and spreading of the virus through multiple organs and results in a fast onset of mortality (starting on Day 6 post infection) in up to 100% of infected fish. During the first phase of viral infections, type I interferons (IFNs) have generally been proven to be essential in inducing an innate immune response; however, very little is known about the type I IFN response to herpesviruses in fish. The aim of this work was to study the type I IFN responses during CyHV-3 infection in 2 genetically divergent lines of common carp which presented differing survival rates. Our results show that CyHV-3 induced a systemic type I IFN response in carp, and the magnitude of type I IFN expression is correlated with the virus load found in skin and head kidney. In this in vivo experimental setup, the level of type I IFN response cannot be linked with higher survival of carp during CyHV-3 infection.
【 授权许可】
Unknown
【 预 览 】
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RO201911300906009ZK.pdf | 330KB | download |