Unusual varieties and duplication of Rig-I like receptors encoded in the marine mollusk, Crassostrea gigas

3rd International Conference on Agricultural and Biological Sciences

农业科学;生物科学

Tian, Z.H.^1 ; Jiao, C.Z.^1

Life Science College, Shaoguan University, Shaoguan

512005, China^1

关键词: Caspase activation;    Crassostrea gigas;    Domain architectures;    Human bodies;    Innate immune response;    Invertebrate species;    Marine mollusk;    Partial duplications;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/77/1/012005/pdf
DOI  :  10.1088/1755-1315/77/1/012005

来源: IOP

【 摘 要 】

RIG-I like receptors (RLRs) play key roles in sensing non-self nucleic acids in cytoplasm and trigger antiviral innate immune response in vertebrates and human body. Here we carried out in silico analysis to identify and investigate the putative RLRs encoded in the genome of marine mollusk, Crassostrea gigas (cgRLRs), an invertebrate species. We found the unusual duplication and varieties on domain architecture of putative cgRLRs encoded in the genome of C. gigas. Three putative cgRLRs (accessions numbers are EKC24603, EKC31344.1 and EKC38304.1 on GenBank), have the similar domain architecture with that of human RIG-I or MDA5, and one protein (EKC34573.1) with that of human LGP2; The fifth putative cgRLRs (EKC38303.1) is somewhat similar with human RIG-I/MDA5 except that it has only one caspase activation and recruitment domain (CARD) in its N-terminal. Other nine proteins were identified to be partialy similar with RLRs while with the incomplete sequences, which maybe reflect the events of partial duplication of cgRLRs genes occurred in the oyster genome.