Serous Cysts Are a Benign Component of the Cyclic Ovary in the Guinea Pig with an Incidence Dependent upon Inhibin Bioactivity

Journal of Veterinary Medical Science

Manao OZAWA³  Chandana B. HERATH³  Gen WATANABE²  Brian K. PETROFF¹  FangXiong SHI²  Kazuyoshi TAYA² 

[1] Department of Molecular and Integrative Physiology, University of Kansas;Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University;Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology

关键词: guinea pig;    inhibin;    ovarian cyst;    passive immunization;    serous cyst;   

DOI  :  10.1292/jvms.64.129

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(52)Cited-By(8)Ovaries were collected from normal cycling female guinea pigs on each day of the estrous cycle (n=5 per day) for histological analysis of ovarian morphology. Three types of ovarian cysts were observed: serous cysts, follicular cysts and parovarian cysts. The most common were serous cysts (cystic rete ovarii), which were present throughout the estrous cycle with an overall incidence of 63.5% (54 out of 85 animals). Follicular cysts occurred in 22.4% of guinea pigs overall (19 out of 85). Only one parovarian cyst (1 out of 85) was observed in the present experiment. Follicular cysts always coincided with serous cysts and were less common during diestrus. The incidence of serous cysts did not vary significantly across the estrous cycle. In a second experiment, cycling female guinea pigs were arrested in a prolonged luteal phase by a progesterone implant in order to achieve ovarian synchrony. They were then treated with inhibin antiserum (0.5 or 1 ml per animal i.v.; n=6 per group) or normal goat serum (controls; n=6 per group). There was a dose dependent increase in the incidence of serous ovarian cysts following passive immunization against the inhibin α-subunit. These results suggest that serous cysts are a normal component of the cyclic guinea pig ovary and that alterations in the inhibin-follicle-stimulating hormone system appear to modulate the incidence of serous ovarian cysts in this species.

【 授权许可】

Unknown