Regulatory Role of Inhibin in Follicle-Stimulating Hormone Secretion and Folliculogenesis in the Guinea Pig1

Journal of Veterinary Medical Science

Manao OZAWA¹  Akira K. SUZUKI²  Gen WATANABE¹  FangXiong SHI¹  Kazuyoshi TAYA¹ 

[1] Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology;Air Pollutants Health Effects Research Team, Environmental Risk Assessment Project, National Institute for Environmental Studies

关键词: FSH;    guinea pig;    immunoneutralization;    inhibin;    unilateral ovariectomy;   

DOI  :  10.1292/jvms.63.1091

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(37)Cited-By(3)The effects of unilateral and bilateral ovariectomy and passive immunization against inhibin on follicle-stimulating hormone (FSH) secretions and follicular development in the guinea pig were investigated. Bilateral ovariectomy decreased plasma immunoreactive (ir-) inhibin rapidly and increased plasma FSH significantly. Unilateral ovariectomy decreased plasma ir-inhibin and increased plasma FSH temporarily, and doubled the number of ova released from the remaining ovary at the subsequent ovulation in guinea pigs. Injection of 1.0 ml inhibin antiserum significantly increased concentrations of plasma FSH at 6 hr onwards and the number of small follicles (100-200 μm in diameter) at 48 hr after the injection in guinea pigs bearing progesterone-containing implants. In vitro bioassay showed that inhibin antiserum could neutralize the suppression of ovarian homogenate on FSH secretion from cultured rat anterior pituitary cells. These results confirm the evidence that the ovary is the main source of inhibin secretion and both in vitro bioassay and passive immunization against inhibin show that the inhibin is a major regulator in the follicular development through FSH secretion in guinea pigs.

【 授权许可】

Unknown