Immunohistochemical Evaluation of Canine Ovarian Cysts

Journal of Veterinary Medical Science

Hiroyuki TANIYAMA³  Kazufumi KAWASAKO³  Minoru OKAMOTO³  Kazuko HIRAYAMA³  Kazuya MATSUDA³  Misa KOMINE³  Yuko AKIHARA³  Tsuyoshi KADOSAWA⁴  Tetsuo OMACHI²  Yumiko SHIMOYAMA³  Yumiko KAGAWA¹ 

[1] NORTH LABO;PATHO LABO;Department of Veterinary Pathobiology, Rakuno Gakuen University;Department of Small Animal Clinical Sciences, Rakuno Gakuen University

关键词: canine;    immunohistochemistry;    ovarian cyst;   

DOI  :  10.1292/jvms.69.1033

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(15)Cited-By(6)To clarify the immunohistochemical characteristics of canine ovarian cysts, 109 canine ovarian cysts (57 cysts of subsurface epithelial structures: SES, 26 graafian follicle cysts, 12 cystic rete ovarii and 14 cysts difficult to classify morphologically) were examined regarding their lining cells immunohistochemically using antibodies against placental alkaline phosphatase (PLAP), S100, inhibin α, desmin and AE1/AE3. Both cysts of SES and cystic rete ovarii had a positive immunoreaction to desmin and AE1/AE3, whereas all cysts all but graafian follicle cysts were negative for inhibin α. PLAP-positive immunoreaction was observed only in cysts of SES. Graafian follicle cysts had a positive immunoreaction to inhibin α, but were negative for PLAP, desmin and AE1/AE3. Fourteen cysts were difficult to classify morphologically because these cysts had single-squamous lining cells and lacked other morphological characteristics. However, these unclassified cysts were immunohistochemically divided into two groups, including positive and negative cysts, by the reactivity of PLAP. The PLAP-positive cysts were considered large cysts of SES. These results suggest that PLAP was a useful marker for classification of cysts of SES, although cysts originating from SES are not always positive for this antigen.

【 授权许可】

Unknown