Anti-Inflammatory Potency of Oral Disulfiram Compared with Dexamethasone on Endotoxin-Induced Uveitis in Rats

Journal of Veterinary Medical Science

Naoyuki ITOH¹  Fumio HOSHI¹  Yasutomo HORI¹  Seiichi HIGUCHI¹  Noriaki NAGAI²  Kazutaka KANAI¹  Seishirou CHIKAZAWA¹  Yoshimasa ITO² 

[1] Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato;Department of Advanced Design for Pharmaceuticals, School of Pharmacy, University of Kinki

关键词: anti-inflammatory potency;    dexamethasone;    diethyldithiocarbamate;    disulfiram;    endotoxin-induced uveitis;   

DOI  :  10.1292/jvms.10-0239

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(2)To investigate potency of oral disulfiram (DSF) compared with that of dexamethasone (Dexa), on endotoxin-induced uveitis (EIU) in rats. The oral administration with 750 mg/kg DSF suppressed the number of inflammatory cells, protein concentration, and levels of tumor necrosis factor (TNF)-α, Nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor and improved the histiologic status of the ocular tissue at 24 hr after lipopolysaccharide (LPS) injection. The anti-inflammatory potency of DSF oral administration was as strong as that observed with 0.5 mg/kg Dexa in the present study. The results suggest that DSF might pave the way for a novel therapeutic agent for the management of uveitis.

【 授权许可】

Unknown