Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice

Bioscience of Microbiota, Food and Health

Shuzo ORIKASA¹  Jin-Zhong XIAO¹  Noriyuki IWABUCHI²  Kazumi NABESHIMA² 

[1] Next Generation Science Institute, Morinaga Milk Industry Co., Ltd., Kanagawa 252-8583, Japan;Food Ingredients and Technology Institute, Morinaga Milk Industry Co., Ltd., Kanagawa 252-8583, Japan

关键词: Bifidobacterium longum BB536;    schizophrenia;    rearing behavior;    apomorphine;    corticosterone;    tryptophan;    kynurenine;   

DOI  :  10.12938/bmfh.2016-004

学科分类：生物科学（综合）

来源: Nihon Bifizusukin Senta / Japan Bifidus Foundation

【 摘 要 】

References(28)Schizophrenia is a chronic psychiatric illness. Disruption of the dopaminergic system has been suggested to be the pathogenic cause of this disease. The effect of Bifidobacterium longum BB536 (BB536) on schizophrenic behavior was investigated in an animal model. Daily administration of BB536 (109 CFU/mouse, p.o. for 2 weeks) was found to reduce rearing behavior augmented by the dopamine receptor agonist apomorphine and to decrease the resting level of plasma corticosterone and the ratio of kynurenine to tryptophan. These results suggest the potential of BB536 for supplemental treatment of the symptoms of schizophrenia.

【 授权许可】

Unknown