Role of the methanolic extracts of Boswellia serrata and Lavandula angustifolia on apomorphine induced ejaculation in male Wistar rats

Dynamic Chiropractic

J. Zaringhalam¹  J. Shams²  Sh. Rezazadeh³  H. Manaheji⁴ 

[1] Department of Physiology, Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.;Institute of Medicinal Plants, ACECR, Tehran, Iran.;Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.

关键词: Ejaculation;    apomorphine;    sexual behavior;    herbal.;   

DOI  :  10.5897/JMPR10.097

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Ejaculation is a complex physiological and psychological process which cholinergic and dopaminergic mechanisms might be involved in regulation of it. Rapid ejaculation is the most frequently encountered sexual complaint of men and different method of treatments were recommended. The aim of this study was to investigate possible role of the methanolic extracts of theBoswellia serrataandLavandulaangustifoliaon ejaculatory responses induced by apomorphinein male Wistar rats. Ejaculation was induced by subcutaneous injection of apomorphine dissolved in saline and was counted by direct observation after drug injection. The effects of methanolic extracts ofB. serrataandL.angustifoliaon apomorphine induced ejaculation were examined. The results showed dose related decrease of semen drop numbers due to extracts administration. During monotherapy the effective doses of both extracts were 100 mg/kg. Combination therapy with bothB. serrateandL.angustifoliaextracts (50,100 mg/kg) significantly decreased semen drop numbers. It was concluded that, mono/combination therapy withB. serrateandL.angustifoliaextracts decreased apomorphine - induced ejaculation and may have a beneficial role in the treatment of rapid ejaculation.

【 授权许可】

Unknown