Painful Ejaculation with Cyclobenzaprine: A Case Report and Literature Review

Sexual Medicine

Molly B. Kraus MD¹  Christopher S. Wie MD¹  Andrew W. Gorlin MD¹  Eric S. Wisenbaugh MD² 

[1] Department of Anesthesiology, Mayo Clinic, Phoenix, AZ, USA;Department of Urology, Mayo Clinic, Phoenix, AZ, USA

关键词: Cyclobenzaprine;    Orgasmic Disorder;    Sexual Dysfunction;    Ejaculation;   

DOI  :  10.1002/sm2.93

来源: Wiley

【 摘 要 】

Abstract

Introduction

Sexual dysfunction is a well-known side effect of antidepressants. Painful ejaculation is a rare side effect that has been reported with the use of some psychiatric drugs such as triclyclic antidepressants. Cyclobenzaprine is a muscle relaxant that is structurally similar to tricyclic antidepressants. It is the most commonly prescribed muscle relaxant in the United States and accounts for 18% of all prescriptions written for chronic back pain.

Methods

A 55-year-old man was referred to our pain medicine clinic for evaluation and treatment of pain with ejaculation.

Main outcome Measure

The main outcome measure was to review the current published literature and case reports on painful ejaculation from medication use, in particular tricyclic antidepressants.

Results

After discontinuation of cyclobenzaprine, our patient's sexual dysfunction resolved. This result was consistent with the literature reviewed on the topic.

Conclusion

Painful ejaculation is likely an underreported side effect of tricyclic antidepressants and cyclobenzaprine use. Fortunately, these symptoms are reversible and discontinuation of these medications is typically an effective cure. Kraus MB, Wie CS, Gorlin AW, Wisenbaugh ES, and Rosenfeld DM. Painful ejaculation with cyclobenzaprine: A case report and literature review. Sex Med 2015;3:343–345.

【 授权许可】

CC BY-NC   
© 2015 The Authors. Sexual Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Sexual Medicine.

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.