Effects of Depletion of T Cell Subpopulations on the Course of Infection and Anti-Parasite Delayed Type Hypersensitivity Response in Mice Infected with Babesia microti and Babesia rodhaini

Journal of Veterinary Medical Science

Naoaki MATSUKI¹  Terumasa SHIMADA¹  Sojin SHIKANO¹  Kenichiro ONO¹  Rie HASHIGUCHI¹ 

关键词: Babesia microti;    Babesia rodhaini;    mouse;    T cell subpopulation;   

DOI  :  10.1292/jvms.58.343

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(29)Cited-By(5)To elucidate the role of T cell subpopulations in the protective cell-mediated immune response at the initial phase of infection with Babesia microti (BM) and B.rodhaini (BR), the changes in the course of infection and anti-parasite delayed type hypersensitivity (DTH) response after BM or BR inoculation were investigated in Lyt-2+ T cell- or L3T4+ T cell-depleted mice. Depletion of Lyt-2+ T cells strongly enhanced the resistance to BM infection, whereas it increased the susceptibility to BR infection. In contrast, depletion of L3T4+ T cells increased susceptibility to BM infection, while it enhanced resistance to BR infection. The anti-parasite DTH response in BM-infected mice was significantly enhanced by depletion of Lyt-2+ T cells, while significantly reduced by depletion of L3T4+ T cells. No effects of depletion of either Lyt-2+ or L3T4+ T cells on DTH response was observed in BR-infected mice. From these results, it was suggested that the roles of Lyt-2+ and L3T4+ T cells in the protective cell-mediated immune response at the initial phase of infection were different between BM- and BR-infected mice, resulting in the difference in their course of infection.

【 授权许可】

Unknown