Changes of Splenic Lymphocyte Subpopulation in Mice inoculated with Babesia microti and Babesia rodhaini

Journal of Veterinary Medical Science

Terumasa SHIMADA¹  Sohjin SHIKANO¹  Naoyoshi SUZUKI¹  Atsushi SAITO¹  Kenichiro ONO¹ 

关键词: Babesia microti;    Babesia rodhaini;    mouse;    splenic lymphocyte;    subpopulation;   

DOI  :  10.1292/jvms.54.1071

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(14)Cited-By(1)Changes of splenic lymphocyte subpopulation after Babesia microti and Babesia rodhaini inoculation in mice were examined by flow cytometric analysis. The B. microti inoculated mice showed a longer period of time from inoculation to the onset of increase or decrease parasitaemia (%), packed cell volume, total spleen cell numbers and surface immunoglobulin positive splenic cell numbers than respective periods in B. rodhaini inoculated mice. The Thy-1 positive cell numbers in B. microti inoculated mice and B. rodhaini inoculated mice pre-immunized with homologous parasites were significantly higher than that of B. rodhaini inoculated mice. The ratio of L3T4 positive cell/Lyt-2 positive cell after inoculation with B. microti was quite similar to that in B. rodhaini mice pre-immunized. However, the ratio in B. rodhaini inoculated mice revealed a lack of an increasing phase. These results suggested that the T-cell dependent early immune response, especially suppressor activity, was closely related to the difference in the course of infection between the non-lethal B. microti and the lethal B. rodhaini infection in mice.

【 授权许可】

Unknown