Prevalence of Circulating Antibodies to p10, a Non-structural Protein of the Borna Disease Virus in Cats with Ataxia

Journal of Veterinary Medical Science

Kazuyoshi IKUTA¹  Masami MOCHIZUKI³  Atsuo OUCHI⁴  Takeshi KOBAYASHI¹  Masahiko KISHI⁴  Patrick K. LAI²  Tahir H. MALIK² 

[1] Research Institute for Microbial Diseases, Osaka University;Department of Biosciences, Salem International University;Laboratory of Clinical Microbiology, Kyoritsu Seiyaku Corporation;Tsukuba Central Laboratories, Kyoritsu Seiyaku Corporation

关键词: anti-BDV antibody;    ataxia;    Borna disease virus;    feline.;   

DOI  :  10.1292/jvms.63.1279

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(45)Cited-By(6)Japanese domestic cats were surveyed for circulating antibodies to the p10 and p24 proteins of the Borna disease virus (BDV) by Western blotting. Twenty-four of 52 cats (46.2%) with ataxia and other neurologic symptoms of unknown cause were positive for antibodies to BDV p10 and/or p24. In contrast, cats without neurological symptoms gave a significantly lower prevalence of anti-BDV antibodies to p10 and/or p24 (36 of 152 cats, 23.7%). Thirty specific pathogen-free (SPF) cats tested as controls were uniformly negative to BDV p10 and p24 antigens. These results suggest that BDV may play a role in ataxia in cats. Additionally, our results suggest that it is necessary to use both p10 and p24 as antigens to detect circulating antibodies to BDV in cats.

【 授权许可】

Unknown