One-hour post-load hyperglycemia by 75g oral glucose tolerance test as a novel risk factor of atherosclerosis

Endocrine Journal

Ippei Kanazawa¹  Ken-ichiro Tanaka¹  Toru Yamaguchi¹  Toshitsugu Sugimoto¹ 

[1] Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo 693-8501, Japan

关键词: Post-load hyperglycemia;    Atherosclerosis;    Intima-media thickness;    75g oral glucose tolerance test;   

DOI  :  10.1507/endocrj.EJ13-0370

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(18)Cited-By(2)Postprandial hyperglycemia is considered as a risk factor of cardiovascular disease.We hypothesized that early post-load hyperglycemia might be more useful surrogate marker to assess atherosclerosis than plasma glucose (PG) level at 120 minutes because the peak of post-load glucose by 75gOGTT is usually shown at 60 minutes.75gOGTT and carotid echography were investigated in 108 subjects who visited our hospital to examine impaired glucose tolerance.The association of post-load plasma glucose and insulin levels with intima-media thickness (IMT) was examined.Simple correlation analyses showed that fasting PG (FPG) (r=0.26, p=0.013), PG60 (r=0.40, p<0.001), PG90 (r=0.29, p=0.008), area under curve for PG (AUC-PG) (r=0.33, p=0.003), HbA1c (r=0.30, p=0.005), amount of PG increase at 60 minutes (PGΔ60) (r=0.39, p=0.002), and PGΔ90 (r=0.27, p=0.016), were significantly correlated with IMT. Multiple regression analysis using IMT as a dependent variable and PG60, FPG, HbA1c, and AUC-PG as independent variables showed that PG60 was only significantly and positively correlated with IMT (β=0.59, p=0.042). Moreover, PG60 and PGΔ60 were significantly and positively associated with IMT even after additional adjustment for classical atherosclerosis risk factors (β=0.30, p=0.005 and β=0.50, p=0.037, respectively). The cut-off values of PG60 and PGΔ60 to detect atherosclerosis (IMT > 1.1mm) were 188 and 101 mg/dL, respectively (p<0.01). These findings show that early post-load hyperglycemia, particularly PG60 is a novel risk factor of atherosclerosis and useful to assess it.

【 授权许可】

Unknown