Low serum free testosterone level is associated with carotid intima-media thickness in middle-aged Japanese men

Endocrine Journal

Norio Nonomura²  Hidenobu Okuda²  Iwao Yoshioka²  Toshiki Moriyama³  Keisuke Yamamoto²  Akira Tsujimura²  Tetsuya Takao²  Yasushi Miyagawa²  Shinichiro Fukuhara²  Ryohei Yamamoto¹  Hiroshi Kiuchi²  Keiko Yamauchi- Takihara³  Makoto Nishida³ 

[1] Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan;Department of Urology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan;Health Care Center, Osaka University, Suita 565-0871, Japan

关键词: Free testosterone;    Carotid artery;    Intima-media thickness;    Atherosclerosis;    Men;   

DOI  :  10.1507/endocrj.EJ12-0060

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(42)Cited-By(6)In the present study, we measured carotid artery intima-media thickness (CIMT) and assessed several metabolic factors in middle-aged healthy Japanese men to clarify the relation between testosterone and atherosclerosis.The study comprised 176 male employees aged ≥40 years who visited Osaka University Healthcare Center for their annual health examinations.Serum total testosterone (TT) concentration was measured using radioimmunoassay (RIA) and serum free testosterone concentration was measured using analog ligand RIA (aFT).A multivariate model adjusted for age, body mass index, mean arterial pressure and treatment for hypertension demonstrated a significant association between aFT and CIMT.Even after adjustment for other clinically relevant factors, the significant association between aFT and CIMT was not attenuated.After adjustment for all other clinically relevant factors, both univariate and multivariate models ascertained the stepwise association that a level of aFT of ≤10.0 pg/mL was significantly associated with CIMT.However, the association between TT and CIMT was not significant in either univariate or multivariate models.We conclude that our finding showing that low serum aFT level is an influencing and independent risk factor for CIMT is of value in the clinical setting because no other studies, to our knowledge, have conducted multivariate analyses using the various metabolic factors included in the present analyses.

【 授权许可】

Unknown