Changes in Plasma Concentrations of Inhibin A and Inhibin B Throughout Sexual Maturation in the Male Chimpanzee

Endocrine Journal

KEIKO SHIMIZU⁶  TAKEFUMI UDONO⁵  MASAHIRO KONDO²  MIHO FUNAKOSHI⁴  NIGEL P GROOME¹  MARIKO ITOH⁶  KAZUYOSHI TAYA³  WANZHU JIN³  GEN WATANABE³ 

[1] School of Biological and Molecular Sciences, Oxford Brookes University;Novartis Animal Health;Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University;Laboratory of Veterinary Physiology, Tokyo University of Agriculture;Kumamoto Primates Research Park, Sanwa Kagaku Kenkyusho, Ltd.;Primate Research Institute, Kyoto University

关键词: Inhibin;    Follicle-stimulating hormone;    Prolactin;    Chimpanzee;    Sexual maturation;   

DOI  :  10.1507/endocrj.47.707

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(21)Cited-By(9)Profiles of circulating plasma inhibin A and inhibin B during sexual maturation in male chimpanzees were investigated by using two-site enzyme-linked immunoassay (ELISA). Plasma concentrations of testosterone and pituitary gonadotropins were also measured. Concentrations of inhibin B, testosterone, luteinizing hormone (LH) and prolactin increased with age throughout prepuberty to adulthood, whereas inhibin A level was low and there were no age-related changes in concentrations of either inhibin A and follicle-stimulating hormone (FSH). Inhibin B showed an inverse correlation with FSH in adult (7 years or order) but not in immature (6 years or younger) male chimpanzees. There was no correlation between plasma levels of FSH and testosterone throughout the period of sexual maturation. However, testosterone levels were positively correlated with inhibin B levels. These results suggest that circulating inhibin B is involved in the regulation of FSH secretion after puberty in adult male chimpanzees, and also that circulating inhibin B is an important form of inhibin as a marker of Sertoli cell function in adult male chimpanzees.

【 授权许可】

Unknown