The Nucleotide and Predicted Amino Acid Sequence of the Fusion Protein of Recent Isolates of Canine Distemper Virus in Japan

Journal of Veterinary Medical Science

Chieko KAI¹  Emi YOSHIDA¹  Takeshi MIKAMI¹  Naoko MIYASHITA¹  Kenjiro OHASHI¹  Yeon-Sil SHIN¹  Kiyoko IWATSUKI¹ 

[1] Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo

关键词: CDV;    field isolate;    fusion protein;   

DOI  :  10.1292/jvms.60.381

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)Cited-By(5)Analysis of the molecular properties of fusion (F) proteins of field isolates of canine distemper virus (CDV) by immunoprecipitation analysis revealed an identical molecular mass of F protein of 3 field isolates as well as the Onderstepoort laboratory strain. Sequencing showed that the F gene of a field isolate (the Yanaka strain) shared 90.1% and 95.7% identities with the Onderstepoort strain at nucleotide and amino acid levels, respectively. All of the 13 cysteine residues and 4 potential asparagine-linked glycosylation sites were completely conserved amongst these strains. These results indicate that the F proteins is much less heterogeneous than that observed in the hemagglutinin proteins of CDV.

【 授权许可】

Unknown