Sequence Analysis of the Genes Encoding the Phosphoprotein of Recent Isolates of Canine Distemper Virus in Japan

Journal of Veterinary Medical Science

Chieko KAI¹  Chiaki WAKASA¹  Kenjiro OHASHI¹  Kazuya NAKAMURA¹  Kiyoko IWATSUKI¹ 

[1] Laboratory of Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan

关键词: CDV;    field isolate;    P gene sequence;   

DOI  :  10.1292/jvms.62.97

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(1)The nucleotide sequences of the phosphoprotein (P) of canine distemper virus (CDV) strains isolated between 1992 and 1996 in Japan were determined. This is the first report of the complete sequences of the P genes of recently prevalent CDV strains. The deduced amino acid sequences of the P, C and V proteins showed that in the new Japanese isolates, these proteins have approximately 93%, 90-91% and 92% identities with those of the Onderstepoort vaccine strain, respectively. The predicted functional regions were conserved. RNA editing resulting in a shift to the open reading frame (ORF) of the V protein was shown to occur with the same efficiency in both the field isolates and vaccine strain.

【 授权许可】

Unknown