Intranasal Administration of Quercetin Liposome Decreases Anxiety-like Behavior and Increases Spatial Memory | Science Publications

American Journal of Agricultural and Biological Sciences

Aroonsri Priprem¹  Saengrawee Suthiparinyanont¹  Jintanaporn Wattanathorn¹  Wathita Phachonpai¹ 

关键词: Quercetin;    liposome;    anxiolytic activity;    cognitive function;    intranasal route;    elevated plus maze;    morris water maze test;   

DOI  :  10.3844/ajabssp.2007.31.35

学科分类：农业科学（综合）

来源: Science Publications

【 摘 要 】

At present, the effects of quercetin liposome on anxiolytic activity and cognitive function are unclearly known. In this study, male Wistar rats were administered quercetin liposome via intranasal route once daily continually for 4 weeks. The anxiolytic activity and cognitive enhancing effect were determined after single administration, 1, 2, 3 and 4 weeks of treatment using elevated plus maze test and Morris water maze test respectively. The results showed that quercetin liposome significantly increased both number of opened arm entry and time spent in the opened arm. In addition, the quercetin liposome also decreased escape latency and increased retention time markedly. Therefore, our results demonstrated the anxiolytic activity and cognitive enhancing effect of quercetin liposome and suggested that it might be used as a novel therapeutic strategy for anxiety disorder and cognitive deficit condition.

【 授权许可】

Unknown