Sedative, anxiolytic and toxicological effect of an aqueous extract from Erythrina berteroana (pito) flowers in mice

Revista Cubana de Plantas Medicinales

Santa Maria, Ana Miriam¹  Espinoza Madrid, Paul²  Moreno, Miguel¹  Nuñez, Marvin J²  Avalos, Jesus Noel²  Toloza, Gonzalo²  Bonilla, Jessica Amanda¹ 

[1] Laboratorio de Investigación en Productos Naturales;Laboratorio de Química Clínica, El Salvador

关键词: subacute toxicity;    anxiolytic activity;    Erythrina berteroana;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Introduction: Erythrina berteroanaUrb., commonly known as pito, is a plant of wide distribution in El Salvador which has traditionally been attributed sedative and anxiolytic properties.Objectives: evaluate the sedative, anxiolytic and toxicological effect of lyophilized aqueous extract of Erythrinaberteroana flowers.Methods: the sedative and anxiolytic effect of the aqueous extract of dried E. berteroana flowers was evaluated at doses of 100, 250 and 500 mg/kg of body weight using unconditioned tests in mice of both sexes. Oral toxicity was also evaluated at a limit dose of 2 000 mg/kg of body weight for 28 days.Results: phytochemical testing revealed the presence of alkaloids, triterpenes and flavonoids in E. berteroana flowers. No alterations were observed in the health status of experimental animals. It was shown that the test substance does not have a sedative effect, but it does have anxiolytic activity, reducing the natural fear of open spaces, heights, spheres and the unknown.Conclusions: results show that E. berteroana aqueous flower extract has no sedative effect, but it does have a slightly effective anxiolytic effect, which could be mainly attributable to the presence of alkaloids and flavonoids in the study substance.

【 授权许可】

CC BY-NC