Protective Effects of Isoliquiritigenin Against Methamphetamine-Induced Neurotoxicity in Mice

Journal of Pharmacological Sciences

Meeyul Hwang¹  Chae Ha Yang²  Jae-Pil Jeon³  Min Jung Lee² 

[1] The Research Center for Biomedical Resource of Oriental Medicine, Daegu Haany University, South Korea;Department of Physiology, Daegu Haany University, South Korea;Division of Biobank for Health Sciences, Korea National Institute of Health, South Korea

关键词: methamphetamine;    neurotoxicity;    isoliquiritigenin;   

DOI  :  10.1254/jphs.09153SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(8)Isoliquiritigenin (ISL) suppresses cocaine-induced extracellular dopamine levels and has a neuroprotective effect in cocaine-treated rat brain. Here, we examine the effect of ISL on methamphetamine-induced striatal neurotoxicity. Repeated injections of methamphetamine cause the loss of striatal dopamine transporter (DAT) and tyrosine hydroxylase (TH). Intraperitoneal injection of ISL prior to methamphetamine injection significantly prevented methamphetamine-induced reduction of DAT and TH. ISL also suppressed methamphetamine-induced activation of glial cells. Moreover, ISL impeded the expression of nitric oxide synthase and the activation of NF-κB through blockage of its phosphorylation. Our results suggest that ISL protects against methamphetamine-induced neurotoxicity by inhibition of NF-κB activation.

【 授权许可】

Unknown