Tissue Plasminogen Activator Is Not Involved in Methamphetamine-Induced Neurotoxicity

Journal of Pharmacological Sciences

Kazuhiro Takuma¹  Ayumi Fukakusa¹  Kiyofumi Yamada¹  Hiroyuki Koike¹  Toshitaka Nabeshima²  Hiroyuki Mizoguchi¹ 

[1] Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Japan;Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences Meijo University, Japan

关键词: methamphetamine;    neurotoxicity;    tissue plasminogen activator;   

DOI  :  10.1254/jphs.SC0070328

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(1)To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-deficient (tPA−/−), and protease activated receptor-1–deficient (PAR-1−/−) mice. METH treatment caused a marked decrease in TH and DAT levels in the striatum of those mice with a similar magnitude. No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo.

【 授权许可】

Unknown