Journal of Pharmacological Sciences | |
Endocytic Regulation of Voltage-Dependent Potassium Channels in the Heart | |
Ikuo Norota1  Yutaro Obara1  Kuniaki Ishii1  | |
[1] Department of Pharmacology, Yamagata University School of Medicine, Japan | |
关键词: endocytosis; voltage-dependent potassium channel; cardiac excitability; clathrin; caveolin; | |
DOI : 10.1254/jphs.12R12CP | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(30)Cited-By(2)Understanding the regulation of cardiac ion channels is critical for the prevention of arrhythmia caused by abnormal excitability. Ion channels can be regulated by a change in function (qualitative) and a change in number (quantitative). Functional changes have been extensively investigated for many ion channels including cardiac voltage-dependent potassium channels. By contrast, the regulation of ion channel numbers has not been widely examined, particularly with respect to acute modulation of ion channels. This article briefly summarizes stimulus-induced endocytic regulation of major voltage-dependent potassium channels in the heart. The stimuli known to cause their endocytosis include receptor activation, drugs, and low extracellular [K+], following which the potassium channels undergo either clathrin-mediated or caveolin-mediated endocytosis. Receptor-mediated endocytic regulation has been demonstrated for Kv1.2, Kv1.5, KCNQ1 (Kv7.1), and Kv4.3, while drug-induced endocytosis has been demonstrated for Kv1.5 and hERG. Low [K+]o–induced endocytosis might be unique for hERG channels, whose electrophysiological characteristics are known to be under strong influence of [K+]o. Although the precise mechanisms have not been elucidated, it is obvious that major cardiac voltage-dependent potassium channels are modulated by endocytosis, which leads to changes in cardiac excitability.
【 授权许可】
Unknown
【 预 览 】
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