Effect of Platelet Activating Factor Antagonist (TCV-309) on Lung Injury in Dogs with Experimentally Endotoxin-Induced Shock

Journal of Veterinary Medical Science

Shozo OKANO¹  Masahiro TAGAWA¹  Norimoto URAKAWA¹ 

关键词: endotoxic shock;    lung injury;    Platelet activating factor antagonist;   

DOI  :  10.1292/jvms.57.751

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(18)Cited-By(1)The effect of TCV-309, a newly developed platelet activating factor (PAF) antagonist, on the wet/dry weight ratio of the lung (index of pulmonary edema) and the pulmonary surface activity (index of pulmonary compliance) was evaluated in comparison with that of CV-3988 (PAF-antagonist). Administration of TCV-309 (1 mg/kg) or CV-3988 (10 mg/kg) significantly reduced the wet/dry weight ratio which was increased by endotoxin administration (3 mg/kg). It also augmented the pulmonary surface activity. Administration of either TCV-309 or CV-3988 alleviated the histologic lesions caused by endotoxic shock. These results suggest that lung injury during endotoxic shock can be controlled by TCV-309 as by CV-3988.

【 授权许可】

Unknown