Changes in Reticuloendothelial Function in Dogs with Endotoxin-Induced Shock

Journal of Veterinary Medical Science

Yasushi HARA¹  Hiroyasu EJIMA¹  Kiyonori FURUKAWA¹  Shozo OKANO¹  Masahiko ONDA¹  Ryo OGAWA¹  Masahiro TAGAWA¹  Norimoto URAKAWA¹  Shigekatsu MOTOYOSHI¹ 

关键词: arterial ketone body ratio;    canine;    endotoxic shock;    lipid emulsion test;    reticuloendothelial function;   

DOI  :  10.1292/jvms.55.607

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(21)Cited-By(1)A shock model was experimentally produced by intravenous injection of a lethal dose (3 mg/kg) of endotoxin under general anesthesia induced by pentobarbital sodium using 7 beagles. The effect of this endotoxic shock on the reticuloendothelial function was investigated. The blood endotoxin concentration peaked immediately after administration and decreased subsequently. However, the value still remained on an increased level (1, 051 pg/ml) even at 360 min after endotoxin treatment. The lipid emulsion test as an index of reticuloendothelial phagocytotic activity and the arterial ketone body ratio as an index of the energy charge in the liver decreased after endotoxin treatment and failed to recover during the experiment. Fibronectin, one of opsonic proteins, tended to decrease after injection of the endotoxin and was significantly (p<0.01) low at 180 and 360 min compared with the value before injection of the endotoxin. These results suggested the depression of the reticuloendothelial function during endotoxin-induced shock.

【 授权许可】

Unknown